Water-dispersible hydroxyapatite nanoparticles synthesized in aqueous solution containing grape seed extract

► A methodology of water-dispersible grape seed polyphenol (GSP) modified hydroxyapatite nanoparticles (nHAp). ► GSP graft ratio is up to 44.3%, phenolic hydroxyls introduced onto the surface of nHAp particles. ► The zeta potential value is up to −26.1 mV while the pure nHAp is −0.36 mV.