کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5362063 1388280 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study on a hydroxypropyl chitosan-gelatin based scaffold for corneal stroma tissue engineering
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Study on a hydroxypropyl chitosan-gelatin based scaffold for corneal stroma tissue engineering
چکیده انگلیسی
Hydroxypropyl chitosan (HPCTS) was crosslinked with gelatin (GEL) and chondroitin sulfate (CS) by 1,4-butanediol diglycidyl ether to synthesize a scaffold. In this study, this scaffold was tested in physical and biological characteristics as a bioactive corneal stroma surrogate. The results showed the scaffold exhibited 83-88% light transmission values at wavelengths of visible light. Besides that, the scaffold had 96% water content and allowed NaCl and glucose to permeate. Moreover, it was suitable for keratocytes growing on its surface. In the biological part, we compared the scaffold with CS-free ones to investigate the potential effect of CS and found out that CS notablely improved cell compatibility of the scaffold.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 255, Issue 20, 30 July 2009, Pages 8701-8705
نویسندگان
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