Process optimization studies of 10-Hydroxycamptothecin (HCPT)-loaded folate-conjugated chitosan nanoparticles by SAS-ionic crosslink combination using response surface methodology (RSM)

► Preparation of HCPT nanoparticles by supercritical antisolvent (SAS) method. ► 10-Hydroxycamptothecin (HCPT)-loaded folate-conjuated chitosan nanoparticles by SAS-ionic crosslink combination method using response surface methodology (RSM). ► FA-HCPT-CSNPs used in drug carrier systems could have potential value in HCPT-sensitive tumors.