کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5362982 | 1388295 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Immobilization of bovine serum albumin on TiO2 film via chemisorption of H3PO4 interface and effects on platelets adhesion Immobilization of bovine serum albumin on TiO2 film via chemisorption of H3PO4 interface and effects on platelets adhesion](/preview/png/5362982.png)
In the present study, bovine serum albumin (BSA) was successfully covalently immobilized on the surface of anatase TiO2 film by a three-step method, i.e. application of H3PO4 chemisorption to increase surface -OH, which increases the amount of coupling 3-aminopropyl-triethoxylsilane (APTES), thus linking with BSA by imide bond using EDC/NHS/MES. There is no significant -OH group increase on rutile film when using the same method of phosphoric acid treatment, which suggest it is difficult for further chemical modification of the rutile film. After covalent immobilization of BSA on anatase film, an improved hemocompatibility of anti-platelet adhesion and aggregation in vitro could be recognized by LDH and SEM analysis. This study suggests BSA-immobilized anatase surface can serve as hemocompatibility material in vivo.
Journal: Applied Surface Science - Volume 254, Issue 9, 28 February 2008, Pages 2712-2719