Surface functionalization of 3D glass-ceramic porous scaffolds for enhanced mineralization in vitro

► 3D macroporous glass-ceramic scaffolds obtained by the sponge replication method. ► Scaffolds present excellent mechanical properties and moderate bioactivity. ► Scaffolds have been surface functionalized by the alkaline phosphatase enzyme (ALP). ► ALP maintains its activity after grafting. ► ALP improves and quickens hydroxyapatite precipitation on scaffold surface.