Characterization of self-assembled decyl bis phosphonate-Collagen layers on titanium by QCM-D and osteoblast-compatibility

► The stability of DBP and Collagen I layer that self-assembled on titanium was very good. ► Osteoblasts showed better activity, proliferation, and differentiation on Collagen I terminated samples and BSA adsorbed samples. ► Ti/DBP/Collagen I surface has the potentiality to provide a implant-bone interface with better biocompatibility.