کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5366550 | 1388350 | 2012 | 7 صفحه PDF | دانلود رایگان |

The synthesis of chemically anchored adenosine with biocompatible poly(2-hydroxylethyl methacrylate) grafted gold nanoparticles (Ado-i-PHEMA-g-AuNPs) was realized by employing a simple strategy. Disulfide-containing poly(2-hydroxylethyl methacrylate) (DT-PHEMA) was initially synthesized by atom transfer radical polymerization (ATRP). The formation of DT-PHEMA was confirmed by 1H-NMR and FT-IR. The molecular weight and molecular weight distribution were found to be 9.6Â kg/mol and 1.40 from GPC analysis. DT-PHEMA was subsequently used for the synthesis of PHEMA-g-AuNPs by a grafting to protocol. The grafting of DT-PHEMA on the surface of AuNPs was confirmed by FT-IR, TGA, XPS, and EDX analyses. The particle size of the PHEMA-g-AuNPs was found to be ca. 5.0Â nm from HR-TEM analysis. Boronic acid was used for functionalization of PHEMA-g-AuNPs, which was then subjected for covalent immobilization with adenosine via strong interaction between free hydroxyl groups of adenosine and boronic acid. Characterization and properties of the Ado-i-PHEMA-g-AuNPs were investigated by taking advantage from FT-IR, XPS, EDX, and UV-visible spectroscopy. The Ado-i-PHEMA-g-AuNPs nanocomposite exhibits a surface plasmon resonance peak at 586Â nm which is red shifted from AuNPs (521Â nm), indicating significant changes of surface property upon PHEMA-adenosine immobilization onto the surface of AuNPs.
Highlights⺠Chemically anchored adenosine with PHEMA grafted gold nanoparticles (Ado-i-PHEMA-g-AuNPs) was synthesized. ⺠Disulfide-containing PHEMA was initially synthesized by ATRP. ⺠DT-PHEMA was used for the synthesis of PHEMA-g-AuNPs by a grafting to protocol. ⺠Boronic acid was used for functionalization of PHEMA-g-AuNPs for covalent immobilization with adenosine. ⺠Characterization and properties of the Ado-i-PHEMA-g-AuNPs were investigated by FT-IR, XPS, EDX, and UV-visible spectroscopy.
Journal: Applied Surface Science - Volume 258, Issue 7, 15 January 2012, Pages 2816-2822