Cystamine immobilization on TiO2 film surfaces and the influence on inhibition of collagen-induced platelet activation

► A new method for improving the haemocompatibility of inorganic materials by exploiting endogenous NO donor is reported. ► Cystamine is successfully immobilized on TiO2 film surface via polydopamine as a linker. ► NO release was evaluated and confirmed by cGMP analysis. ► Collagen-induced platelet activation is significantly inhibited on cystamine modified surfaces.