Infrared spectroscopy of hydrated N-(2-phenylethyl)acetamide clusters: The electron-redistribution within the solute weakens local hydrogen bond

► The IR-dip spectroscopy has been applied to investigate the H-bond interaction of the hydrated NPEA cluster cation. ► The spatially separated water molecules influence their intermolecular interactions. ► The electrons are redistributed to enhance the total intermolecular interactions in the D0 state of hydrated NPEA cluster.