The asymmetry of the differential bond polarizabilities in the Raman optically active (+)-(R)-methyloxirane and l-alanine

► The differential bond polarizabilities from the Raman optically active is derived. ► Two systems of (+)-(R)-methyloxirane and l-alanine were analyzed by this approach. ► The asymmetry of the differential bond polarizabilities are demonstrated. ► The methine possesses the largest charge excitation during the Raman process. ► The differential bond polarizabilities adhered to C-H bond are of opposite signs.