Mechanism resulting in chemical imbalance due to cellular damage associated with mechanoporation: A molecular dynamics study

- Molecular dynamics simulation of ion transport through transmembrane pores.
- Ionic disturbance found for pores with radii (ri) greater than 1.5 nm.
- ri of 2.0 nm exhibit large changes in intra- and extra-cellular ionic concentrations.
- Influx of Na+ and Cl− ions is greater than efflux of K+.
- Increase of the cytosolic solute concentration causes an osmotic influx of water.