Acidity and metal (Mg2+, Ca2+, Zn2+) affinity of l-γ-carboxyglutamic acid and its peptide analog

Density functional theory methods with the B3LYP and B97D functionals with triple-zeta 6-311++G(d,p) basis set have been used to study the acidity, basicity and metal affinity of l-γ-carboxyglutamic acid (GLA) and its peptide derivative [2-acetylamino-3-(methylamino)-3-oxopropyl]malonic acid (AMD-GLA).