Molecular insights into the stabilization of protein-protein interactions with small molecule: The FKBP12-rapamycin-FRB case study

- Protein-protein interactions are potential target for drug discovery.
- Protein-protein interactions stabilization is an emerging strategy for drug design.
- Stabilization of the FKBP12-rapamycin-FRB complex by the small molecule rapamycin is described.