Comment on 'Molecular driving forces of the pocket-ligand hydrophobic association' by G. Graziano, Chem. Phys. Lett. 533 (2012) 95

► G. Graziano gave an alternative interpretation of our cavity-ligand binding study. ► We show why this interpretation is inappropriate in our view. ► We note the important role of solvent reorganization for binding thermodynamics.