Analysis of DNA deformation patterns in nucleosome core particles based on isometric feature mapping and continuous wavelet transform

► A collective structural signal is extracted from the NCP DNA path using Isomap. ► The signal accounts for the coupled slide-roll-twist behavior. ► The high-frequency feature of the structural signal is consistent for all the NCPs. ► The low-frequency feature of the structural signal reveals individual differences. ► Peaks and valleys of fluctuation energy are enriched in GC and AC/GT, respectively.