Correlation of 1JCH spin-spin coupling constants and their solvent sensitivities

► Solvent induced changes of 1JCH coupling constants depend on solvent polarity. ► Solvent polarity dependencies of 1JCH are linear in reaction field coordinates. ►1JCH obtained by extrapolation to zero reaction field is close to gas phase value. ► Slope of 1JCH dependency is interpreted as its solvent sensitivity. ► Solvent sensitivities and zero field values of 1JCH are linearly correlated.