The influence of water-ethanol mixture on the thermodynamics of complex formation between 18-crown-6 ether and l-phenylalanine

► IT calorimetric titration and 1Н and 13С NMR spectroscopy. ► Thermodynamic of [Phe18C6] molecular complex formation in H2O-EtOH mixtures. ► Increase of EtOH leads to increase of logКo [Phe18C6] and exothermicity ΔrHo of reaction.