Properties of oxidized phospholipid monolayers: An atomistic molecular dynamics study

► We model oxidized DOPC monolayers with molecular dynamics and potential of mean force. ► Orientational reversal of oxidized chains toward water phase occurs. ► Accumulation of oxidized lipids in the monolayer is observed, nonanal evaporates. ► Massive oxidation causes loss of the structure and solubilization of oxidized lipids.