Hydration property of globular proteins: An analysis of solvation free energy by energy representation method

► Molecular dynamics simulations of five globular proteins (BPTI, RNase A, Lysozyme, β-lactoglobulin A, and α-chymotrypsinogen A). ► Estimation of solvation free energies of the five proteins with explicit solvent by energy representation method. ► Discussion about the hydrophilic property of the proteins with the calculated results.