Cyclodextrin-surfactant binding constant as driven force for uncomplexed cyclodextrin in equilibrium with micellar systems

► β-CD binds alkyl sulfonates forming 1:1 host-guest complexes. ► Uncomplexed β-CD is present in equilibrium with the micellar system. ► Decreasing the hydrophobicity of the surfactant increases the percentage of uncomplexed cyclodextrin.