FRONTIERS ARTICLETip-enhanced Raman Spectroscopy - Its status, challenges and future directions

Tip-enhanced Raman Spectroscopy (TERS) has shown promise as a tool for in situ nanoscale chemical analysis, and is also leading to a better understanding of the fundamentals of surface-enhanced Raman Spectroscopy. In this work, the latest developments, challenges and applications of TERS are discussed. The focus is on tip plasmonics, single molecule detection and nanoscale chemical analysis of biological samples.

Tip-enhanced Raman Spectroscopy (TERS) still faces some challenges, but is becoming a useful analytical tool for nondestructive chemical characterization of many different kinds of nanoscale objects.