Preparation and size optimisation of silica nanoparticles using statistical analyses

Variation of reagent concentrations using statistical analyses (factorial design) was used for the first time to optimise the preparation of small sized silica nanoparticles with small standard deviation. 3-D surface contour models of the first (A) and second (B) statistical studies where reagent concentrations were chosen as factors to be varied (TEOS - tetraethylorthosilicate).