The effect of temperature and solvation on the ultrafast dynamics of N-methylacetamide

The ultrafast dynamics of N-methylacetamide (NMA), a peptide-linkage model compound, are reported as a function of temperature and dilution. The rotational-diffusive timescale of NMA exhibits sudden changes consistent with a model in which neat NMA forms hydrogen bonded aggregates that are disrupted by increased temperature or decreased NMA concentration.