Exceeding the limit of dynamics studies on biomolecules using high spin-lock field strengths with a cryogenically cooled probehead

► Cryogenically cooled probes can safely generate ν1 fields up to 6.4 kHz for 15N. ► Demonstration of large spin-lock fields for relaxation dispersion experiments. ► Efficient removal of contributions from chemical exchange slower than 25 μs. ► Increased resolution between τc and the dispersion time window by a factor of 2. ► Increased sensitivity for motion induced chemical shift variances.