Slice-selective broadband refocusing pulses for the robust generation of crushed spin-echoes

► Slice-selective broadband 180° refocusing pulses (S-BREBOP) designed with optimal control theory. ► Optimized for generating crushed spin-echoes in point-resolved spectroscopy (PRESS). ► Broad bandwidth over range of ±20% B1 scalings. ► Reduce chemical-shift displacement error by factor of 2.5 compared to conventional Shinnar-Le Roux pulses. ► Increase lactate signal in phantom and human brain tumor.