Quantifying conformational dynamics using solid-state R1ρ experiments

► Quantitative exchange rates were obtained with solid state R1ρ relaxation studies. ► Reorientation of the CSA tensor in d6-DMS was used as the probe of exchange. ► Exchange rates and activation energies are in agreement with literature values. ► The ability to quantify R20 and temperature limit the accuracy of the method. ► Methodological considerations for application to protein systems are given.