Dynamic changes in oxygenation of intracranial tumor and contralateral brain during tumor growth and carbogen breathing: A multisite EPR oximetry with implantable resonators

► Six to ten times better S/N ratio with IRs as compared to LiPc deposits. ► EPR oximetry provides repeated assessment of glioma and contralateral brain pO2. ► F98 glioma are hypoxic and pO2 declined with glioma growth over days. ► Glioma oxygenation with carbogen declined in experiments repeated for 5 days.