FLAMEnGO: A fuzzy logic approach for methyl group assignment using NOESY and paramagnetic relaxation enhancement data

► A new assignment procedure (FLAMEnGO) for methyl groups based on NOEs. ► FLAMEnGO uses fuzzy logic, Monte Carlo sampling, and probability-based assignments. ► High tolerance for ambiguous and/or sparse NOE data. ► PREs can be used to reduce the ambiguity in methyl group assignments.