Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra

► Lorentzian-shaped 3-pool-model function for z-spectra. ► Range of spillover influence by FWHM evaluation of direct water saturation. ► Determination of MT and CEST effect without further knowledge of the system. ► Scope of practical application estimated by Monte-Carlo simulation: moderate B1, high SNR, and high sampling rate.