Exchange enhanced sensitivity gain for solvent-exchangeable protons in 2D 1H-15N heteronuclear correlation spectra acquired with band-selective pulses

► Experimental observation of significant sensitivity gain for backbone amides in exchange with water. ► This exchange enhanced sensitivity gain achievable for amides in exchange with water at ca 1-10 s−1. ► The sensitivity gain is expected to be achievable in sequences beyond SOFAST-HMQC.