Compressed sensing and the reconstruction of ultrafast 2D NMR data: Principles and biomolecular applications

► Non-linear processing can speed up NMR/MRI experiments via non-regular sampling of indirect domains. ► These needs are no longer relevant in “ultrafast” protocols where the number of experiments has collapsed to one. ► Yet it is shown that the non-linear sampling of direct domain data enhances ultrafast NMR's sensitivity. ► A compressed sensing algorithm exploiting these principles is demonstrated on the HSQC of 15N-labeled Ubiquitin.