Selective detection of hyperpolarized NMR signals derived from para-hydrogen using the Only Para-hydrogen SpectroscopY (OPSY) approach

► A new family of NMR pulse sequences reported for the recording of para-hydrogen enhanced NMR spectra. ► Only Para-hydrogen SpectroscopY (OPSY) approach uses coherence selection to separate hyperpolarized signals from those of fully relaxed and thermally equilibrated protons. ► Sequence design, performance, practical aspects and applicability to other hyperpolarization techniques discussed.