On the measurement of 15N-{1H} nuclear Overhauser effects. 2. Effects of the saturation scheme and water signal suppression

► The effect of the proton offset in 15N-{1H} NOE experiments is investigated. ► Various proton irradiation schemes are compared under normal and extreme conditions. ► Radiation damping may lead to inaccurate intensities in the reference experiment. ► A recipe to record 15N-{1H} NOE's is presented.