Enhanced sensitivity current density imaging

One of the major weaknesses of current density imaging (CDI) is its poor sensitivity and therefore a need for the use of high voltage in CDI. In this work, a new CDI technique with enhanced sensitivity (ES-CDI) is presented. The ES-CDI sequence overcomes the sensitivity problem in samples with a long T2 relaxation time that allows the use of a long current encoding period. As successful CDI detection is conditioned by a sufficiently large product of current and its application time a longer current encoding period enables the use of lower current and also lower voltage therefore significantly reducing any sample damage. In addition, the ES-CDI sequence also uses fast image signal acquisition and so enables heavy signal averaging and with it associated additional CDI sensitivity increase within the experiment time of the conventional CDI experiment. The feasibility of the ES-CDI sequence was tested on a model sample filled with physiological solution. Voltage of just 1 V and current application time of 800 ms were sufficient to detect current density of 20 A/m2 with a detection limit of 0.7 A/m2.