کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5406728 | 1393186 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Field strength dependence of PRESS timings for simultaneous detection of glutamate and glutamine from 1.5 to 7Â T
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Field strength dependence of PRESS timings for simultaneous detection of glutamate and glutamine from 1.5 to 7Â T Field strength dependence of PRESS timings for simultaneous detection of glutamate and glutamine from 1.5 to 7Â T](/preview/png/5406728.png)
چکیده انگلیسی
An optimization of the PRESS sequence for magnetic resonance spectroscopy is presented to simultaneously detect the important brain metabolites of glutamate (Glu) and glutamine (Gln) at field strengths of 1.5, 3, 4.7, and 7Â T. Standard, clinical examinations typically use short echo times which in general are not ideal for the separation of Glu and Gln. The optimization procedure is based on numerical product operator simulations to produce yield and overlap measurements for all possible practical choices of PRESS inter-echo timings. The simulations illustrate the substantial modulations in Glu and Gln with field strength. At all field strengths, the optimized timings demonstrate a significant reduction in overlap compared to short echo PRESS, while maintaining a high metabolite signal, with Glu and Gln yields >90% when excluding T2 relaxation losses. Minimal overlap was attained at 7Â T (0.3% Gln contamination in the Glu signal), and 4.7Â T (1.2%). The optimized timings were applied in vivo on healthy volunteers at field strengths of 1.5 and 4.7Â T.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetic Resonance - Volume 203, Issue 1, March 2010, Pages 66-72
Journal: Journal of Magnetic Resonance - Volume 203, Issue 1, March 2010, Pages 66-72
نویسندگان
Jeff Snyder, Alan Wilman,