کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5406758 | 1393187 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast
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کلمات کلیدی
DNPhyperpolarizationHyperpolarized waterAngiography - آنژیوگرافیOverhauser effect - اثر OverhauserMRI - امآرآی یا تصویرسازی تشدید مغناطیسیFlow imaging - تصویربرداری جریانMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیDynamic nuclear polarization - قطبش هسته ای پویاFringe field - میدان مغناطیسیPolyvinylimidazole - پلی وینیلیمیدازولRELIC - یادگار
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We describe and demonstrate a system to generate hyperpolarized water in the 0.35Â T fringe field of a clinical 1.5Â T whole-body magnetic resonance imaging (MRI) magnet. Once generated, the hyperpolarized water is quickly and continuously transferred from the 0.35Â T fringe to the 1.5Â T center field of the same magnet for image acquisition using standard MRI equipment. The hyperpolarization is based on Overhauser dynamic nuclear polarization (DNP), which effectively and quickly transfers the higher spin polarization of free radicals to nuclear spins at ambient temperatures. We visualize the dispersion of hyperpolarized water as it flows through water-saturated systems by utilizing an observed â15-fold DNP signal enhancement with respect to the unenhanced 1H MRI signal of water at 1.5Â T. The experimental DNP apparatus presented here is readily portable and can be brought to and used with any conventional unshielded MRI system. A new method of immobilizing radicals to gel beads via polyelectrolyte linker arms is described, which led to superior flow Overhauser DNP performance compared to previously presented gels. We discuss the general applicability of Overhauser DNP of water and aqueous solutions in the fringe field of commercially available magnets with central fields up to 4.7Â T.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetic Resonance - Volume 205, Issue 2, August 2010, Pages 247-254
Journal: Journal of Magnetic Resonance - Volume 205, Issue 2, August 2010, Pages 247-254
نویسندگان
Mark D. Lingwood, Ting Ann Siaw, Napapon Sailasuta, Brian D. Ross, Pratip Bhattacharya, Songi Han,