کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5407508 | 1393219 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Dynamic nuclear polarization of metabolically active compounds labeled with 13C has been introduced as a means for imaging metabolic processes in vivo. To differentiate between the injected compound and the various metabolic products, an imaging technique capable of separating the different chemical-shift species must be used. In this paper, the design and testing of a pulse sequence for rapid magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C is presented. The pulse sequence consists of a small-tip excitation followed by a double spin echo using adiabatic refocusing pulses and a “flyback” echo-planar readout gradient. Key elements of the sequence are insensitivity to calibration of the transmit gain, the formation of a spin echo giving high-quality spectral information, and a small effective tip angle that preserves the magnetization for a sufficient duration. Experiments in vivo showed three-dimensional coverage with excellent spectral quality and SNR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetic Resonance - Volume 187, Issue 2, August 2007, Pages 357-362
Journal: Journal of Magnetic Resonance - Volume 187, Issue 2, August 2007, Pages 357-362
نویسندگان
Charles H. Cunningham, Albert P. Chen, Mark J. Albers, John Kurhanewicz, Ralph E. Hurd, Yi-Fen Yen, John M. Pauly, Sarah J. Nelson, Daniel B. Vigneron,