کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5423854 | 1507947 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A new ethylene glycol-silane monolayer for highly-specific DNA detection on Silicon Chips
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A new ethylene glycol-silane monolayer for highly-specific DNA detection on Silicon Chips A new ethylene glycol-silane monolayer for highly-specific DNA detection on Silicon Chips](/preview/png/5423854.png)
چکیده انگلیسی
Monolayer thin films with ethylene-glycol function onto gold surfaces by using thiols have been extensively investigated. They have been proposed as precursors for applications to bio-detection, where their hydrophilic character improves both specificity and sensitivity. The aim of this letter is to characterize ethylene-glycol monolayer precursors formed onto silicon chips by using silanes. The importance of the ethylene-glycol function is demonstrated by comparing with the well known 3-Aminopropyltriethoxysilane. The different nano-scale structures of the two precursor monolayers are investigated by using atomic force microscopy (AFM). Longer, wider, and deeper grooves were measured in the images acquired on 3-Aminopropyltriethoxysilane. Fluorescence investigation demonstrates that the presence of ethylene-glycol function improves target hybridization onto silicon chips, assuring highly-specific detection of DNA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surface Science - Volume 604, Issues 23â24, November 2010, Pages L71-L74
Journal: Surface Science - Volume 604, Issues 23â24, November 2010, Pages L71-L74
نویسندگان
Sandro Carrara, Andrea Cavallini, Yuki Maruyama, Edoardo Charbon, Giovanni De Micheli,