کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5443853 | 1510952 | 2017 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural analysis of the foldecture derived from racemic peptide foldamers
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سرامیک و کامپوزیت
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The molecular packing structure of an elongated parallelogram plate shaped foldecture composed of a 1:1 racemic mixture of 11-helical peptide foldamers was resolved by powder X-ray diffraction (PXRD) analysis. A comprehensive Rietveld refinement procedure compensated for powder texture and identified the principal face of the foldecture. Each foldamer makes head-to-tail intermolecular hydrogen bonds, creating extended chains of single enantiomers that form a network of hydrophobic close contacts with foldamers of both the opposite and the same chiralities. An isosurface for anisotropic microstrain was calculated and found to be smallest along the x-axis, which is parallel to the network of intermolecular hydrogen bonds. Comparison with the single crystal structure found molecular packing motifs to be almost identical-a result infrequently observed in enantiopure foldectures. This is the first powder X-ray diffraction structural analysis of a foldecture composed of multiple components.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Solid State Sciences - Volume 70, August 2017, Pages 1-5
Journal: Solid State Sciences - Volume 70, August 2017, Pages 1-5
نویسندگان
Jintaek Gong, Jae-Hoon Eom, Rokam Jeong, Russell W. Driver, Hee-Seung Lee,