کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5467444 | 1398937 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Study of the matrix effect on the PIXE quantification of active pharmaceutical ingredients in different formulations
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سطوح، پوششها و فیلمها
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چکیده انگلیسی
The matrix effect on the quantification of the three heteroatoms (chlorine, sulfur and bromine) related to the above API's in different formulations has been studied. In fact, chlorine which is in its hydrochloride form in the API was not eventually considered for calculation due to its instability under beam. The calculation of bromine amount via its Kα or its Lα rays was found to be independent of the matrix composition and it was rapidly done by simple comparison to an external standard. However, the calculation of sulfur, via its Kα, was highly dependent on the matrix composition. Therefore, to achieve an accurate quantification a more sophisticated calculation method was used by means of the GUPIX code.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms - Volume 406, Part A, 1 September 2017, Pages 119-123
Journal: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms - Volume 406, Part A, 1 September 2017, Pages 119-123
نویسندگان
Alice Bejjani, Manale Noun, Maher Soueidan, Serge Della-Negra, Edmond Abi-Fadel, Mohammad Roumie, Bilal Nsouli,