کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5491409 | 1525006 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MR imaging findings in mild traumatic brain injury with persistent neurological impairment
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کلمات کلیدی
SWIMicrohemorrhageMild TBI - TBI خفیفTraumatic brain injury - آسیب تروماتیک مغزFLAIR - اشتباهMRI - امآرآی یا تصویرسازی تشدید مغناطیسیfluid-attenuated inversion recovery - بازیابی معکوس مایعHyperintensities - بیش فعالیDetection - تشخیصsusceptibility-weighted imaging - تصویربرداری با حساسیت پذیریSensitivity - حساسیتLitigation - دعوی قضاییSubcortical - زیرکوهیdeep - عمیقwhite matter - ماده سفید
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Traumatic brain injury (TBI) is a widespread cause of neurologic disability, with >Â 70% of cases being mild in severity. Magnetic resonance imaging provides objective biomarkers in the diagnosis of brain injury by detecting brain lesions resulting from trauma. This paper reports on the detection rates of presumed trauma-related pathology using fluid-attenuated inversion recovery (FLAIR) and susceptibility-weighted imaging (SWI) in TBI patients with chronic, persistent symptoms. Methods: 180 subjects with persistent neurobehavioral symptoms following head trauma referred by personal injury attorneys and 94 asymptomatic, age-matched volunteers were included in the study. 83% of TBI subjects were classified as mild. Results: TBI subjects had a significantly greater number of lesions detected by FLAIR than controls (42% vs. 22%) and more lesions detected by SWI than controls (28% vs. 3%). To reduce the confounding effects of aging, we examined mild TBI subjects <Â 45Â years of age, which reduced the rate of lesions detected by FLAIR (26% vs. 2%) and SWI (15% vs. 0%). This younger group, which contained few age-related lesions, also demonstrated that subcortical lesions on FLAIR are more specific for TBI than deeper lesions. Conclusions: While the presence of litigation in mild TBI cases with incomplete recovery has been associated with greater expression of symptomatology and, by extension, poorer outcomes, this study shows that mild TBI patients in litigation with chronic, persistent symptoms may have associated brain injury underlying their symptoms detectable by MRI biomarkers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 37, April 2017, Pages 243-251
Journal: Magnetic Resonance Imaging - Volume 37, April 2017, Pages 243-251
نویسندگان
Gabriela Trifan, Ramtilak Gattu, Ewart Mark Haacke, Zhifeng Kou, Randall R. Benson,