کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5491530 | 1525003 | 2017 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Can transverse relaxation rates in deep gray matter be approximated from functional and T2-weighted FLAIR scans for relative brain iron quantification?
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کلمات کلیدی
GREEPIFLAIR - اشتباهfluid-attenuated inversion recovery - بازیابی معکوس مایعEcho-planar imaging - تصویربرداری اکو فلاریfMRI - تصویرسازی تشدید مغناطیسی کارکردیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیgradient recalled echo - گرادیان اکو را به یاد می آورد
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Alterations in iron concentration in certain deep gray matter regions are known to occur in aging and several clinical conditions. In vivo measurements of R2â transverse relaxation rates and quantitative susceptibility mapping (QSM) have been shown to be strongly correlated with iron concentration in tissue, but their calculation requires the acquisition of a multi-echo gradient recalled echo sequence (MGRE). In the current study, we examined the feasibility of approximating R2â rates using metrics derived from fMRI-EPI and T2-weighted FLAIR images, which are widely available. In a sample of 40 healthy subjects, we obtained these metrics (vEPI and vFLAIR), as well as R2â rates and QSM estimates, and found significant correlations between vEPI and vFLAIR and R2â rates in several subcortical gray matter regions known to accumulate iron, but not in a control corticospinal white matter region. These relationships were preserved after referencing vEPI and vFLAIR with respect to the values in the control region. Effect sizes (above 0.5 for some of the regions, particularly the largest ones) were calculated and put in relation to those of the correlation between QSM and R2â rates. We propose that the metrics described here may be applied, possibly in a retrospective fashion, to analyze datasets with available EPI or T2-weighted FLAIR scans (and lacking a MGRE sequence), to devise new hypotheses regarding links between iron concentration in brain tissue and other variables of interest.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 40, July 2017, Pages 75-82
Journal: Magnetic Resonance Imaging - Volume 40, July 2017, Pages 75-82
نویسندگان
BenjamÃn Garzón, Rouslan Sitnikov, Lars Bäckman, Grégoria Kalpouzos,