کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5499391 | 1400017 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Entsorgung radioaktiv kontaminierter Reststoffe aus der Ga-68-PET - Berechnung eines Freigabewertes für Ge-68+
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
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![عکس صفحه اول مقاله: Entsorgung radioaktiv kontaminierter Reststoffe aus der Ga-68-PET - Berechnung eines Freigabewertes für Ge-68+ Entsorgung radioaktiv kontaminierter Reststoffe aus der Ga-68-PET - Berechnung eines Freigabewertes für Ge-68+](/preview/png/5499391.png)
چکیده انگلیسی
Ga-68-labeled radiotracers, particularly used for the detection of neuroendocrine tumors by means of Ga-68-DOTA-TATE or -DOTA-TOC or for the diagnosis of prostate cancer by means of Ga-68-labeled antigens (Ga 68-PSMA), become increasingly important. In addition to the high sensitivity and specificity of these radiopharmaceuticals, the short-lived radionuclide Ga-68 offers almost ideal nuclear characteristics for use in PET. Ga-68 is obtained from a germanium-gallium-generator system, so that the availability of Ga-68-labeled radiotracers is independent of an on-site-cyclotron regardless of the short half-life of Ga-68 of about 68Â minutes. Regarding the disposal of the radioactively contaminated waste from the preparation of the radiopharmaceutical, the eluted Ga-68 has to be considered to be additionally contaminated with its parent nuclide Ge-68. Due to this production-related impurity in combination with the short half-life of Ga-68, the radioactive waste has to be considered to be contaminated with Ge-68 and Ga-68 in radioactive equilibrium (hereafter referred to as Ge-68+). As there are no clearance levels for Ge-68+ given in the German Radiation Protection Ordinance, this work presents a method to calculate the missing value basing on a recommendation of the German Radiation Protection Commission in combination with simple geometric models of practical radiation protection. Regarding the relevant exposure scenarios, a limit value for the unrestricted clearance of Ge-68+ of 0.4 Bq/g was determined.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Zeitschrift für Medizinische Physik - Volume 27, Issue 1, March 2017, Pages 49-55
Journal: Zeitschrift für Medizinische Physik - Volume 27, Issue 1, March 2017, Pages 49-55
نویسندگان
Alexander Solle, Carsten Wanke, Lilli Geworski,