کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5500683 1534303 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
123I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
123I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies
چکیده انگلیسی
Cardiac meta-iodobenzylguanidine (MIBG) uptake on 123I-MIBG cardiac scintigraphy is reduced in patients with Lewy body disease such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pure autonomic failure, and has been reported to be useful for differentiating PD from other parkinsonian syndromes, as well as DLB from Alzheimer disease (AD). Postmortem studies have shown that the number of tyrosine hydroxylase (TH)-immunoreactive nerve fibers of the heart was decreased in pathologically-confirmed Lewy body disease, supporting the findings of reduced cardiac MIBG uptake in Lewy body diseases. Now, reduced cardiac MIBG uptake can be a potential biomarker for the presence of Lewy bodies in the nervous system. 123I-MIBG cardiac scintigraphy can allow us to determine the presence of Lewy bodies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 30, September 2016, Pages 122-133
نویسندگان
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