کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5501285 | 1534845 | 2017 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence](/preview/png/5501285.png)
چکیده انگلیسی
Ageing of the human immune system, or immunosenescence, is characterised by distinct changes in the proportion of the various cell types, e.g., increase of the CD14 + monocytic cells, decrease of CD19 + B lymphocytes, and changes in T cell subpopulations, namely increase of CD4 + and CD8 + cells which have lost the costimulatory CD28 antigen. Currently, it is believed that the lifelong antigenic burden may be one of the inducers of immunosenescence. Thus far, only one exogenous stimulus, cytomegalovirus infection, has shown to be a major factor in this respect. To find other possible candidates, we evaluated the role of the evolutionary youngest group of human endogenous retroviruses, namely HERV-K(HML-2), on immunosenescence. HERVs exist in the genome as proviruses, but their activation has been detected in several immunopathologic conditions. The expression of HERV-K(HML-2) env was observed to be lower in the peripheral blood mononuclear cells of nonagenarians (n = 61) than in those of young controls (n = 37). These mRNA levels did not correlate with the age-associated differences in the proportions of CD14 +, CD4 + CD28 â and CD8 + CD28 â cells, but in the case of CD19 + B cells a strong positive correlation was observed in the nonagenarians. Thus, these data suggest that HERVs do not function as antigenic drivers of immunosenescence. On the contrary, expression of HERV-K(HML-2) env is associated with more youthful levels of B cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 97, 15 October 2017, Pages 60-63
Journal: Experimental Gerontology - Volume 97, 15 October 2017, Pages 60-63
نویسندگان
Saara Marttila, Tapio Nevalainen, Juulia Jylhävä, Laura Kananen, Marja Jylhä, Antti Hervonen, Mikko Hurme,