CD4/CD8 ratio < 1 is associated with lymphocyte subsets, CMV and gender in 71-year old individuals: 5-Year follow-up of the Swedish HEXA Immune Longitudinal Study

- CD4/CD8 ratio < 1, CMV IgG + status and T cell repertoire and response are associated.
- Changes over 5 years for CD3 +, CD4 +, CD8 +, CD19 + and CD4/CD8 ratio are found.
- The proportion of individuals with CD4/CD8 ratio < 1 increases over 5 years.
- The proportion of individuals with CD4/CD8 ratio < 1 was higher in men than in women.
- There was no significant association between CD4/CD8 ratio < 1 and 5-year mortality.