کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5501322 1534848 2017 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in adipose tissue cellular composition during obesity and aging as a cause of metabolic dysregulation
ترجمه فارسی عنوان
تغییرات ترکیب سلولی بافت چربی در طی چاقی و پیری به عنوان یک علت اختلال در تنظیم متابولیسم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Adipose tissue represents complex endocrine organ containing several different cellular populations including adipocytes, pre-adipocytes, mesenchymal stem cells, macrophages and lymphocytes. It is well establishing that these populations are not static but alter during obesity and aging. Changes in cellular populations alter inflammatory status and other common metabolic complications arise, therefore adipose tissue cellular composition helps dictate its endocrine and regulatory function. During excessive weight gain in obese individuals and as we age there is shift towards increase populations of inflammatory macrophages with a decrease of regulatory T cell. This altered cellular composition promote chronic low grade inflammation negatively affecting mesenchymal stem cell progenitor self-renewal, which result in deterioration of adipogenesis and increased cellular stress in adipocytes. All these changes promote metabolic disorders including age- or obese-related insulin resistance leading to type 2 diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 94, August 2017, Pages 59-63
نویسندگان
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