کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5501442 1534853 2017 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes of renin-angiotensin system-related aminopeptidases in early stage Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Changes of renin-angiotensin system-related aminopeptidases in early stage Alzheimer's disease
چکیده انگلیسی
Consideration of the data for the two time points for AD patients showed that the changes in ApB occurred at an early stage of the disease and persisted, whilst those of ApA and ApN only became apparent at later stages of the disease. Although differences in Michaelis-Menten parameters were not statistically significant, consideration of the values suggested that the decrease in ApB activity may be a result of changes in enzyme protein conformation, whilst that of ApN may be a consequence of decreased enzyme expression. Importantly, the different time courses of the effects and the differential changes in enzyme affinity and expression indicated that the observed changes with progression of AD were not a 'class effect' for serum aminopeptidases but were idiosyncratic for the individual enzymes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 89, March 2017, Pages 1-7
نویسندگان
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