کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5501563 1534850 2017 40 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective roles of nanomelatonin in cerebral ischemia-reperfusion of aged brain: Matrixmetalloproteinases as regulators
ترجمه فارسی عنوان
نقش محافظتی نانومولاتونین در ایسکمی مغز و رپرفیوژن مغز سالم: ماتریکس متالوپروتئینازها به عنوان تنظیم کننده
کلمات کلیدی
ایسکمی-ریپرسیشن مغزی، مانع خون مغزی، ملاتونین نانو کپسول شده، ماتریکس متالوپروتئیناز، گونه های اکسیژن واکنش پذیر،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Cerebral ischemia-reperfusion (CIR) injury occurs as a result of oxygen occlusion in the carotid artery through embolus or thrombus formation or cerebrovascular hemorrhage. The oxygen thrust during reperfusion causes the generation of reactive oxidative species (ROS) which exert a potential threat to neuronal survival. ROS may possibly be arrested by antioxidants. After CIR, extracellular matrix remodeling takes place, which is governed by matrix metalloproteinases (MMPs). Augmentation of lipid per oxidation, perturbation of antioxidant enzyme activities and the loss of pyramidal neuronal cells in rat brain were attributed to CIR injury. Melatonin can readily cross the blood-brain barrier (BBB) to exert protective effects as an antioxidant but it is quickly cleared by the circulating blood. Also melatonin is easily degraded by light and hence is found to be ineffective during daytime. Results of the present study showed that unlike free melatonin (FM), the application of nanocapsulated melatonin (NM) exhibited significantly higher potential even at much lower concentrations to rescue neuronal cells and mitochondria during CIR insult and also restored the activities of antioxidative enzymes and MMPs to their normal levels. Hence, nanoencapsulated melatonin may be considered as a suitable drug delivery system for brain to exert protection against CIR injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 92, June 2017, Pages 13-22
نویسندگان
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