کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5502782 | 1535091 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Botulinum toxin as early intervention for spasticity after stroke or non-progressive brain lesion: A meta-analysis
ترجمه فارسی عنوان
توکسین بوتولینوم به عنوان مداخله اولیه برای اسپاستیک پس از سکته مغزی یا آسیب مغزی غیر مغزی: یک متاآنالیز
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کلمات کلیدی
VASPSSPost-stroke spasticityBoNT-ASMDARAT - آراتSpasticity - اسپاستیسیته یا اسپاستیسیتی modified Ashworth scale - اصلاح مقیاس AshworthLower limb - اندام تحتانیUpper limb - اندام زبرین، اندام فوقانیMAS - بیشترAction Research Arm Test - تست بازوی تحقیقاتی اقدامStandard mean difference - تفاوت میانگین استانداردRehabilitation - توانبخشیRange of motion - دامنه حرکتROM - رامbotulinum toxin - سم بوتولینومBotulinum toxin type A - سم بوتولینوم نوع Aadverse event - عارضه جانبی یا عوارض جانبیvisual analogue scale - مقیاس آنالوگ بصریGoal Attainment Scaling - مقیاس رسیدن به هدفGas - گاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Spasticity is a functionally limiting disorder that commonly occurs following stroke or severe brain injury, and may lead to disability and pain. In tandem with neurorehabilitation, botulinum toxin type A (BoNT-A) is the recommended first-line treatment for spasticity and, to date, the majority of trials have reported BoNT-A use in patients >Â 6Â months after ictus. The present meta-analysis aimed to evaluate the effects of early BoNT-A injection for post-stroke spasticity on improvements in hypertonicity, disability, function and associated pain. A literature search yielded six studies reporting the effects of BoNT-A treatment within 3Â months post-stroke; three in the upper limb and three in the lower limb. All six studies permitted concomitant rehabilitation. Reduction in hypertonicity was compared in all six studies and revealed a significant treatment effect (PÂ =Â 0.0002) on the most affected joints between weeks 4 and 12 following injection. However, no significant effects of treatment were observed for improvement in disability at week 4 or improvement in function at weeks 4 and 20-24. A trend towards reduction in spasticity-related pain at week 4 following BoNT-A treatment (PÂ =Â 0.13) was also observed. These results demonstrate the beneficial effects of BoNT-A treatment on improving hypertonicity within 3Â months post-stroke and emphasise the importance of concomitant neurorehabilitation therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 371, 15 December 2016, Pages 6-14
Journal: Journal of the Neurological Sciences - Volume 371, 15 December 2016, Pages 6-14
نویسندگان
Raymond L. (Professor), Fran Efendy, Ericka SA Teleg, Mary MD Delos Santos, Mary CE Rosales, Marc Ostrea, Michelle J Tanglao, Arlene R. Ng,